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. 2004 Jan;70(1):76-8.
doi: 10.1055/s-2004-815462.

In vitro antimalarial activity of biflavonoids from Wikstroemia indica

Shinyu Nunome  1 , Aki Ishiyama, Miyuki Kobayashi, Kazuhiko Otoguro, Hiroaki Kiyohara, Haruki Yamada, Satoshi Omura
Affiliations

In vitro antimalarial activity of biflavonoids from Wikstroemia indica

Shinyu Nunome et al. Planta Med. 2004 Jan.

Abstract

In our investigation of in vitro antimalarial screening of medicinal herbal extracts, the n-BuOH extract from the root of Wikstroemia indica showed a potent inhibitory effect. Fractionation of the active extract led to the isolation of two biflavonoids, sikokianin B ( 1) and sikokianin C ( 2) with IC (50) values 0.54 microg/mL and 0.56 microg/mL, respectively, against the chloroquine-resistant strain of Plasmodium falciparum. This is the first report of the biological activity of 1 and 2. As the structure of l has remained unsettled, we confirmed the conformation by (1)H- and (13)C-NMR.

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