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Review
. 1992 Nov;13(11):449-54.
doi: 10.1016/0167-5699(92)90074-H.

The extrathymic T-cell development pathway

B Rocha  1 , P Vassalli, D Guy-Grand
Affiliations
Review

The extrathymic T-cell development pathway

B Rocha et al. Immunol Today. 1992 Nov.

Abstract

In normal mice, not all T-lineage cells are generated and selected in the thymus; an alternative, extrathymic, development pathway exists. Extrathymic T cells are rare in the spleen and lymph nodes, but are abundant in some tissues, such as the gut. Here, Benedita Rocha, Pierre Vassalli and Delphine Guy-Grand discuss the rules of selection of extrathymic T cells, assess the possible role of these cells in the defence of epithelial integrity and their potential role in autoimmune disease.

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