AMPA receptor activation; not a square dance
- PMID: 14766169
- DOI: 10.1016/s0896-6273(04)00040-6
AMPA receptor activation; not a square dance
Abstract
AMPA receptors are tetramers assembled as a dimer-of-dimers with a 2-fold rotational symmetry in their extracellular domains. Two papers in this issue of Neuron, by Horning and Mayer and Sobolevsky et al., provide complementary data that extend this view and highlight the role of dimers in channel gating.
Comment on
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The outer pore of the glutamate receptor channel has 2-fold rotational symmetry.Neuron. 2004 Feb 5;41(3):367-78. doi: 10.1016/s0896-6273(04)00008-x. Neuron. 2004. PMID: 14766176
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Regulation of AMPA receptor gating by ligand binding core dimers.Neuron. 2004 Feb 5;41(3):379-88. doi: 10.1016/s0896-6273(04)00018-2. Neuron. 2004. PMID: 14766177
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