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. 2004 Feb;42(2):888-90.
doi: 10.1128/JCM.42.2.888-890.2004.

Genetic analysis of an ambler class A extended-spectrum beta-lactamase from Capnocytophaga ochracea

Anne Jolivet-Gougeon  1 , Zohreh Tamanai-Shacoori, Laurent Desbordes, Nathalie Burggraeve, Michel Cormier, Martine Bonnaure-Mallet
Affiliations

Genetic analysis of an ambler class A extended-spectrum beta-lactamase from Capnocytophaga ochracea

Anne Jolivet-Gougeon et al. J Clin Microbiol. 2004 Feb.

Abstract

A beta-lactamase gene (cfxA3, 966 bp) was isolated from a beta-lactam-resistant Capnocytophaga ochracea clinical isolate and amplified using primers from the cfxA gene of Bacteroides vulgatus. The MICs of third-generation cephalosporins were much higher than those of the transconjugant Escherichia coli strain. The deduced protein sequence, by comparison with CfxA2 of Prevotella intermedia, had a Y239D substitution and possessed the characteristics of a class A, group 2e beta-lactamase.

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