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. 2004 Feb;46(2):104-12.
doi: 10.1097/01.jom.0000111963.64211.3b.

Immune markers and ornithine decarboxylase activity among electric utility workers

Travers Y Ichinose  1 , James B Burch, Curtis W Noonan, Michael G Yost, Thomas J Keefe, Annette Bachand, Rosemonde Mandeville, John S Reif
Affiliations

Immune markers and ornithine decarboxylase activity among electric utility workers

Travers Y Ichinose et al. J Occup Environ Med. 2004 Feb.

Abstract

The effects of a 60-Hz magnetic field (MF) exposure on white blood cell ornithine decarboxylase (ODC) activity, natural killer (NK) cell activity, lymphocyte phenotypes, and differential cell counts were studied among 60 electric utility workers. Personal MF exposure monitoring over 3 consecutive workdays was followed by collection of a peripheral blood sample. There were no MF-related changes in NK activity or the number of circulating neutrophils, eosinophils, basophils, or T-lymphocytes (CD4, CD8, CD4:CD8 ratio). MF exposure intensity was associated with decreased ODC activity (P<0.01) and lower NK cell counts (P=0.04). Melatonin production, which stimulates the immune system, was quantified on the night preceding immune marker determinations. Exposure-related reductions in ODC activity, NK and B cells, and monocytes were strongest among workers with reduced melatonin production. The biological significance or long-term health consequences associated with these changes are not known.

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