Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 Feb 15;189(4):648-51.
doi: 10.1086/381535. Epub 2004 Feb 4.

Significant changes of peripheral T lymphocyte subsets in patients with severe acute respiratory syndrome

Taisheng Li  1 , Zhifeng Qiu, Linqi Zhang, Yang Han, Wei He, Zhengyin Liu, Xiaojun Ma, Hongwei Fan, Wei Lu, Jing Xie, Huanling Wang, Guohua Deng, Aixia Wang
Affiliations

Significant changes of peripheral T lymphocyte subsets in patients with severe acute respiratory syndrome

Taisheng Li et al. J Infect Dis. .

Abstract

This report demonstrates that a rapid decrease of peripheral T cell subsets is a unique characteristic in patients with SARS during acute infection, although total white blood cell counts, red blood cell counts, and platelet counts remain relatively normal. In recovering patients, a rapid and dramatic restoration of peripheral T cell subsets was seen in the periphery. Although the underlying mechanism of the acute decrease of peripheral T cell subsets observed in patients with SARS during the acute stage remains unknown, this clinical characteristic can facilitate an earlier and more accurate diagnosis of SARS.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Comparison of peripheral changes in CD3, CD4, and CD8 T cell counts in patients who have severe acute respiratory syndrome (SARS) (A) and among healthy individuals and those infected with the SARS virus, HIV-1, cytomegalovirus (CMV), or Epstein-Barr virus (EBV) (B).
Figure 2.
Figure 2.
Comparison of peripheral changes in CD3, CD4, and CD8 T cell; B cell; and NK cell counts in patients with severe acute respiratory syndrome during acute infection, in patients who have recovered from the illness, and in healthy individuals.
See this image and copyright information in PMC

References

    1. Peiris JS, Lai ST, Poon LL, et al. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet. 2003361:1319–25 - PMC - PubMed
    1. Drosten C, Gunther S, Preiser W, et al. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med. 2003348:1967–76 - PubMed
    1. Ksiazek TG, Erdman D, Goldsmith CS, et al. A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med. 2003348:1953–66 - PubMed
    1. Tsang KW, Ho PL, Ooi GC, et al. A cluster of cases of severe acute respiratory syndrome in Hong Kong. N Engl J Med. 2003348:1977–85 - PubMed
    1. Peiris J, Chu CM, Cheng V, et al. Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study. Lancet. 2003361:1767–72 - PMC - PubMed

MeSH terms