[Research of cross-linking reagent for producing hyaluronic acid derivative]

Abstract

Objective: To review the recent advances of cross-linking reagent for producing hyaluronic acid (HA) derivative so as to provide more advice for the development of HA reagent.

Methods: Recent original articles related to the species, characteristic, cross-linking methodology and mechanism of the cross-linking reagent to producing HA derivative were summarized and systematically analyzed.

Results: The derivatives after special kinds of reagents modification would remain their own good biocompatibility and change their original rheololgical characterization and obtain relative long organism residence time.

Conclusion: Development of hyaluronic derivatives may widen their medical application.