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Comment
. 2004 Feb 17;101(7):1793-4.
doi: 10.1073/pnas.0308172101. Epub 2004 Feb 9.

Stepwise helix formation and chain compaction during protein folding

Heinrich Roder  1
Affiliations
Comment

Stepwise helix formation and chain compaction during protein folding

Heinrich Roder. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig. 1.
Fig. 1.
Sequential four-state mechanism involving two partially structured ensembles, I1 and I2, in addition to the acid-unfolded (U) and native (N) states. Cartoons of the different states are consistent with the fraction of helical residues (fH) and radius of gyration (Rg) reported in ref. . Cylinders indicate the approximate position of α-helices in the native state and possible arrangement of core helices in the intermediates consistent with amide protection data (17).
See this image and copyright information in PMC

Comment on

References

    1. Baldwin, R. L. & Rose, G. D. (1999) Trends Biochem. Sci. 24, 26–33. - PubMed
    1. Dill, K. A., Bromberg, S., Yue, K., Fiebig, K. M., Yee, D. P., Thomas, P. D. & Chan, H. S. (1995) Protein Sci. 4, 561–602. - PMC - PubMed
    1. Uzawa, T., Akiyama, S., Kimura, T., Takahashi, S., Ishimori, K., Morishima, I. & Fujisawa, T. (2004) Proc. Natl. Acad. Sci. USA 101, 1171–1176. - PMC - PubMed
    1. Callender, R. H., Dyer, R. B., Gilmanshin, R. & Woodruff, W. H. (1998) Annu. Rev. Phys. Chem. 49, 173–202. - PubMed
    1. Eaton, W. A., Munoz, V., Hagen, S. J., Jas, G. S., Lapidus, L. J., Henry, E. R. & Hofrichter, J. (2000) Annu. Rev. Biophys. Biomol. Struct. 29, 327–359. - PMC - PubMed

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