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Review
. 1992 Oct;46(1-4):85-111.
doi: 10.1016/0304-3991(92)90008-8.

Has negative staining still a place in biomacromolecular electron microscopy?

A Bremer  1 , C Henn, A Engel, W Baumeister, U Aebi
Affiliations
Review

Has negative staining still a place in biomacromolecular electron microscopy?

A Bremer et al. Ultramicroscopy. 1992 Oct.

Abstract

Transmission electron microscopy of proteins has provided molecular- and in a few cases near-atomic-resolution structural information. In this review, we critically evaluate the potential and the limitations in obtaining molecular resolution, particularly with negatively stained specimens, and put these into perspective with cryomicroscopy of unstained frozen-hydrated and sugar-embedded preparations.

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