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. 1951 Jun;93(6):523-7.
doi: 10.1084/jem.93.6.523.

Studies on immunity in anthrax. II. In vitro elaboration of protective antigen by non-proteolytic mutants of Bacillus anthracis

G G WRIGHT, M A HEDBERG, R J FEINBERG

Studies on immunity in anthrax. II. In vitro elaboration of protective antigen by non-proteolytic mutants of Bacillus anthracis

G G WRIGHT et al. J Exp Med. 1951 Jun.

Abstract

Non-proteolytic mutants were isolated from the Vollum strain of B. anthracis following ultraviolet treatment. The mutants were virulent for rabbits and mice and their non-proteolytic character was stable in culture and on serial passage in rabbits. The mutants produced protective antigen under suitable conditions of cultivation in vitro, and allowed longer incubation of the cultures without destruction of the protective antigen than did the parent strain. The meaning of the results is discussed.

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References

    1. J Infect Dis. 1949 Jan-Feb;84(1):92-7 - PubMed
    1. J Exp Med. 1945 Jun 1;81(6):573-92 - PubMed