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. 1992 Nov;30(11):1411-8.
doi: 10.1016/0041-0101(92)90516-8.

Effects of canatoxin on the Ca(2+)-ATPase of sarcoplasmic reticulum membranes

E W Alves  1 , A T Ferreira, C T Ferreira, C R Carlini
Affiliations

Effects of canatoxin on the Ca(2+)-ATPase of sarcoplasmic reticulum membranes

E W Alves et al. Toxicon. 1992 Nov.

Abstract

Canatoxin, a toxic protein isolated from the seeds of Canavalia ensiformis, was studied for its effects on the sarcoplasmic reticulum vesicles obtained from rabbit skeletal muscle. Canatoxin inhibited Ca2+ accumulation catalysed by the Ca(2+)-ATPase, without affecting the hydrolytic activity of this enzyme or membrane permeability to Ca2+. The effects of canatoxin were dose dependent, but not time dependent. It is concluded that canatoxin interacts with the Ca2+ pump and uncouples Ca2+ uptake from Ca(2+)-dependent ATP hydrolysis.

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