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. 1992 Dec;51(12):1330-1.
doi: 10.1136/ard.51.12.1330.

Methotrexate treatment of rheumatoid arthritis: is a fortnightly maintenance schedule enough?

M Tishler  1 , D Caspi, M Yaron
Affiliations

Methotrexate treatment of rheumatoid arthritis: is a fortnightly maintenance schedule enough?

M Tishler et al. Ann Rheum Dis. 1992 Dec.

Abstract

In 15 patients with rheumatoid arthritis who were in clinical remission the weekly regimen of methotrexate treatment was changed to fortnightly without a change in dose. A total of 13 patients completed a 12 month trial. No change in clinical or laboratory parameters occurred. There was no change in the use of analgesics or non-steroidal anti-inflammatory drugs and the patients remained in remission. Two patients had to be withdrawn after two and four months respectively because of a flare in disease activity. It is suggested that in most patients with rheumatoid arthritis who are treated with methotrexate and whose disease activity is stable a fortnightly regimen can be permitted without affecting drug efficacy.

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References

    1. J Rheumatol. 1991 Jul;18(7):978-83 - PubMed
    1. Arthritis Rheum. 1988 Feb;31(2):167-75 - PubMed
    1. Ann Rheum Dis. 1988 Aug;47(8):654-9 - PubMed
    1. Br Med J. 1972 Mar 11;1(5801):654-6 - PubMed
    1. Am J Med. 1987 Apr;82(4):781-6 - PubMed