Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1951 Sep;94(3):213-21.
doi: 10.1084/jem.94.3.213.

The half-life of passively acquired antibody globulin molecules in infants

A S WIENER

The half-life of passively acquired antibody globulin molecules in infants

A S WIENER. J Exp Med. 1951 Sep.

Abstract

By following the titer of passively acquired Rh antibodies in newborn infants, it is calculated that the half-life of the placenta-passing Rh antibody molecule is approximately 30 days. Evidence is offered that this estimate applies not only to placenta-passing Rh antibodies, but also to other placenta-passing antibodies, and not improbably to serum gamma globulin molecules in general. Studies on the fate of free Rh antibodies in erythroblastotic babies show that these antibodies often are eliminated no more rapidly in Rh-positive babies than in Rh-negative babies. On the other hand, incompatible alpha and beta antibodies, as a rule, are quickly neutralized and eliminated from the body of newborn infants. These observations provide one explanation for the lower incidence of erythroblastosis due to A-B sensitization in comparison with cases resulting from Rh sensitization.

PubMed Disclaimer

References

    1. Am J Obstet Gynecol. 1949 Feb;57(2):312-22 - PubMed
    1. Lancet. 1949 Aug 20;2(6573):324-6 - PubMed
    1. J Exp Med. 1934 Feb 28;59(3):269-82 - PubMed