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Comparative Study
. 1992 Oct;11(10):943-5.
doi: 10.1007/BF01962381.

Comparative activity of the topical quinolone OPC-7251 against bacteria associated with acne vulgaris

K Vogt  1 , J Hermann, U Blume, H Gollnick, H Hahn, U F Haustein, C E Orfanos
Affiliations
Comparative Study

Comparative activity of the topical quinolone OPC-7251 against bacteria associated with acne vulgaris

K Vogt et al. Eur J Clin Microbiol Infect Dis. 1992 Oct.

Abstract

The antibacterial activity of the topical quinolone OPC-7251 against bacteria commonly found in acne vulgaris was tested in vitro by an agar dilution method. The MIC50 was 0.25 mg/l for Propionibacterium acnes, 0.125 mg/l for Propionibacterium granulosum, 0.03 mg/l for Staphylococcus aureus and 0.06 mg/l for coagulase-negative staphylococci. Compared with seven other antibiotics tested (ciprofloxacin, penicillin, erythromycin, tetracycline, clindamycin, fusidic acid and gentamicin), OPC-7251 had potent activity against both propionibacteria and staphylococci and the lowest incidence of resistant strains.

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References

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