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. 2004 Feb 1;64(3):969-76.
doi: 10.1158/0008-5472.can-03-2592.

RTVP-1, a tumor suppressor inactivated by methylation in prostate cancer

Chengzhen Ren  1 , Likun Li, Guang Yang, Terry L Timme, Alexei Goltsov, Chenghui Ren, Xiaorong Ji, Josephine Addai, Hongbin Luo, Michael M Ittmann, Timothy C Thompson
Affiliations

RTVP-1, a tumor suppressor inactivated by methylation in prostate cancer

Chengzhen Ren et al. Cancer Res. .

Abstract

We previously identified and characterized a novel p53-regulated gene in mouse prostate cancer cells that was homologous to a human gene that had been identified in brain cancers and termed RTVP-1 or GLIPR. In this report, we document that the human RTVP-1 gene is also regulated by p53 and induces apoptosis in human prostate cancer cell lines. We show that the expression of the human RTVP-1 gene is down-regulated in human prostate cancer specimens compared with normal human prostate tissue at the mRNA and protein levels. We further document epigenetic changes consistent with RTVP-1 being a tumor suppressor in human prostate cancer.

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