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Clinical Trial
. 2004 Feb 10;62(3):486-8.
doi: 10.1212/01.wnl.0000106944.59990.e6.

Second-line anticonvulsant treatment of neonatal seizures: a video-EEG monitoring study

G B Boylan  1 , J M Rennie, G Chorley, R M Pressler, G F Fox, K Farrer, M Morton, C D Binnie
Affiliations
Clinical Trial

Second-line anticonvulsant treatment of neonatal seizures: a video-EEG monitoring study

G B Boylan et al. Neurology. .

Abstract

The authors conducted a randomized trial of second-line anticonvulsant treatments for neonates. The response to treatment was assessed using continuous video-EEG because the clinical diagnosis of seizure in neonates is known to be unreliable. Of 27 neonates with EEG-confirmed seizures, 5 were excluded because of protocol violations, and 11 responded to phenobarbitone in a dose of 40 mg/kg as first line. Three of five neonates treated with lignocaine responded. Six neonates were treated with benzodiazepines as second line: None responded, and their neurodevelopmental outcome was poor.

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