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Clinical Trial
. 1992 Nov;10(4):347-9.
doi: 10.1007/BF00944194.

Phase II trial of merbarone in soft tissue sarcoma. A Southwest Oncology Group study

E H Kraut  1 , J Bendetti, S P Balcerzak, J H Doroshow
Affiliations
Clinical Trial

Phase II trial of merbarone in soft tissue sarcoma. A Southwest Oncology Group study

E H Kraut et al. Invest New Drugs. 1992 Nov.

Abstract

Thirty-seven patients with advanced soft tissue sarcoma were treated with merbarone utilizing a daily intravenous schedule for five days. Only one partial response was observed in the thirty-three evaluable patients. The major toxicities were renal, with elevation of creatinine and/or proteinuria, and gastrointestinal, with mild to moderate nausea and vomiting. Merbarone in this dose and schedule has minimal activity in soft tissue sarcoma.

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