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Clinical Trial
. 1992 Nov;7(2):95-9.

Diagnosis and clinical use of bromperidol in HIV-related psychoses in a sample of seropositive patients with brain damage

P Perretta  1 , C Nisita, E Zaccagnini, A Scasso, A Nuccorini, M D Santa, G B Cassano
Affiliations
  • PMID: 1487628
Clinical Trial

Diagnosis and clinical use of bromperidol in HIV-related psychoses in a sample of seropositive patients with brain damage

P Perretta et al. Int Clin Psychopharmacol. 1992 Nov.

Abstract

We evaluated in an open trial the safety and effectiveness of a high-potency neuroleptic (bromperidol) for the treatment of AIDS-related organic mental syndromes. Eleven (nine men and two women) seropositive patients with psychotic features were included; six were intravenous drug users (IVDU) and five were not IVDU (NON-IVDU). On the basis of the achievement of a CGI score of 1 or 2 (much improved or very much improved) at the fourth week, nine patients were considered responders, one was a partial responder and one was a non-responder. From a clinical point of view, "positive" psychotic symptoms had a significant remission, while the "negative" ones seemed to be less sensitive or insensitive to bromperidol treatment.

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