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. 1992 Dec;325(12):797-801.
doi: 10.1002/ardp.19923251210.

[Thiophene as a structural element of physiologically active substances. 20. Thiophene analogs of the leukotriene D4 antagonist Ro 23-3544]

[Article in German]
D Binder  1 , A Koch, F Rovenszky, H Stroissnig
Affiliations

[Thiophene as a structural element of physiologically active substances. 20. Thiophene analogs of the leukotriene D4 antagonist Ro 23-3544]

[Article in German]
D Binder et al. Arch Pharm (Weinheim). 1992 Dec.

Abstract

The synthesis of 6-Acetyl-7-[[5-(5-acetyl-4-hydroxy-3-propyl-2-thienyl- oxy)pentyl]oxy]-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid (1), a thiophene analogue of the leukotriene antagonist Ro 23-3544, is described. Compound 1 shows almost no effect on leukotriene D4 induced broncho-constriction on anesthesized guinea pigs.

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