doi: 10.1089/aid.1992.8.1945.
A CD4-derived peptide carrier blocks acute HIV-1 infection in vitro and binds to gp120 in the presence of Walter-Reed stage 1-6 HIV+ sera
Affiliations
- PMID: 1489581
- DOI: 10.1089/aid.1992.8.1945
Item in Clipboard
A CD4-derived peptide carrier blocks acute HIV-1 infection in vitro and binds to gp120 in the presence of Walter-Reed stage 1-6 HIV+ sera
AIDS Res Hum Retroviruses.
1992 Nov.
Abstract
A peptide containing amino acid residues 41-84 of the CD4 molecule was synthesized and coupled through a thioether bond to human serum albumin. This conjugate bound to gp120 with an affinity that was half that of CD4 and blocked the HIV infection in vitro with an efficacy tenfold lower than that of CD4. More importantly, the CD4 peptide-human serum albumin conjugate could bind to gp120 in the presence of HIV+ sera from 18 Walter Reed stage 1-6 patients.
Similar articles
-
CD4 peptide-protein conjugates, but not recombinant human CD4, bind to recombinant gp120 from the human immunodeficiency virus in the presence of serum from AIDS patients.Proc Natl Acad Sci U S A. 1991 Jul 1;88(13):5690-3. doi: 10.1073/pnas.88.13.5690. Proc Natl Acad Sci U S A. 1991. PMID: 2062847 Free PMC article.
-
[Peptides from the principal neutralizing and CD4-binding domain: similar immunoreactive properties and structure pattern].Vestn Ross Akad Med Nauk. 1992;(9-10):47-52. Vestn Ross Akad Med Nauk. 1992. PMID: 1283721 Review. Russian.
-
Critical role of Arg59 in the high-affinity gp120-binding region of CD4 for human immunodeficiency virus type 1 infection.Virology. 2007 Jun 20;363(1):69-78. doi: 10.1016/j.virol.2006.12.003. Epub 2007 Feb 23. Virology. 2007. PMID: 17320923
-
The effect of low-profile serine substitutions in the V3 loop of HIV-1 gp120 IIIB/LAI on the immunogenicity of the envelope protein.Virology. 1998 Nov 10;251(1):59-70. doi: 10.1006/viro.1998.9392. Virology. 1998. PMID: 9813203
-
B cell antigenic site mapping of HIV-1 glycoproteins.Chem Immunol. 1993;56:34-60. Chem Immunol. 1993. PMID: 8452653 Review. No abstract available.
Cited by
-
Combination effect on HIV infection in vitro of soluble CD4 and HIV-neutralizing antibodies.Arch Virol. 1994;134(1-2):179-84. doi: 10.1007/BF01379116. Arch Virol. 1994. PMID: 8279954
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
Research Materials
