Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1992 Dec;12(6):597-606.
doi: 10.1007/BF00711239.

Effects of chronic antidepressant treatment on dopamine-related [3H]SCH 23390 and [3H]spiperone binding in the rat striatum

P R Paetsch  1 , A J Greenshaw
Affiliations
Comparative Study

Effects of chronic antidepressant treatment on dopamine-related [3H]SCH 23390 and [3H]spiperone binding in the rat striatum

P R Paetsch et al. Cell Mol Neurobiol. 1992 Dec.

Abstract

1. The effects of chronic administration of antidepressants on dopamine-related [3H]SCH 23390 and [3H]spiperone binding to rat striatal membranes were assessed. 2. The monoamine oxidase inhibitors phenelzine (5 or 10 mg kg-1/day) and tranylcypromine (1 mg kg-1/day) and the tricyclic desipramine (10 mg kg-1/day) were administered for 28 days by constant subcutaneous infusion using Alzet (2ML4) osmotic minipumps. 3. These treatments did not alter Kd estimates for either [3H]SCH 23390 or [3H]spiperone binding sites. The monoamine oxidase inhibitors induced a decrease in the Bmax values for both [3H]SCH 23990 and [3H]spiperone binding sites. Desipramine induced a decrease in the Bmax value for [3H]SCH 23390 binding but had no effect on the Bmax value for [3H]spiperone binding.

PubMed Disclaimer

References

    1. Andén, N.-E., and Gabrowska-Andén, M. (1987). Increased motor activity following combined simulation of B-HT 920-sensitive and D1 dopamine receptors.Acta Physiol. Scand.131157–158. - PubMed
    1. Anderson, P. H., Gingrich, J. A., Bates, M. D., Dearry, A., Falardeau, P., Senogles, S. E., and Caron, M. G. (1990). Dopamine receptor subtypes: Beyond the D1/D2 classification.Trends Pharmacol. Sci.11231–236. - PubMed
    1. Baker, G. B., and Greenshaw, A. J. (1989). Effects of long-term administration of antidepressants and neuroleptics on receptors in the central nervous system.Cell. Mol. Neurobiol.91–44. - PMC - PubMed
    1. Bland, R. C. (1985). Clinical features of affective disorders. I. Diagnosis, classification, rating scales, outcome and epidemiology. InPharmacotherapy of Affective Disorders (W. G. Dewhurst and G. B. Baker, Eds.), Croom Helm, London, pp. 185–230.
    1. Bunzow, J. R., Van Tol, H. H. M., Grandy, D. K., Albert, P., Salon, J., Christie, J., Machida, C. A., Neve, K. A., and Civelli, O. (1988). Cloning and expression of a rat D2 dopamine receptor cDNA.Nature336783–787. - PubMed

Publication types

LinkOut - more resources