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. 1978;7(2-3):85-91.
doi: 10.1159/000214240.

Studies on assays for plasma prekallikrein and for the monitoring of coumarol therapy

N Egberg, K Bergström

Studies on assays for plasma prekallikrein and for the monitoring of coumarol therapy

N Egberg et al. Haemostasis. 1978.

Abstract

Chromogenic substrates were used to assay prekallikrein, prothrombin and factor X. Plasma prekallikrein was contact activated and allowed the splitting of HD-Pro-Phe-Arg-PNA which has affinity for plasma kallikrein. Prothrombin was assayed in various ways (immunologically, after activation with Ecarin or in a less specific way). Determination of factor X is considered as a possible specific method in the monitoring of coumarol therapy.

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