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. 1992 Dec;45(12):1853-66.
doi: 10.7164/antibiotics.45.1853.

Pneumocandins from Zalerion arboricola. I. Discovery and isolation

R E Schwartz  1 , D F Sesin, H Joshua, K E Wilson, A J Kempf, K A Goklen, D Kuehner, P Gailliot, C Gleason, R White, et al.
Affiliations
Free article

Pneumocandins from Zalerion arboricola. I. Discovery and isolation

R E Schwartz et al. J Antibiot (Tokyo). 1992 Dec.
Free article

Abstract

HPLC bioautography of the directed biosynthesis of Zalerion arboricola led to the discovery of pneumocandin B0 (L-688,786), a new antifungal and anti-Pneumocystis carinii lipopeptide. Isolation techniques were developed to separate this component from pneumocandin A0 (L-671,329) in fermentations of a mutant of Zalerion arboricola. A number of related compounds were also isolated, which differ from pneumocandins A0 and B0 in the hydroxylation patterns on the ornithine, homotyrosine, and proline.

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