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Review
. 1992 Dec;8(12):408-12.
doi: 10.1016/0168-9525(92)90322-u.

V(D)J recombination gets a break

M Gellert  1
Affiliations
Review

V(D)J recombination gets a break

M Gellert. Trends Genet. 1992 Dec.

Abstract

The diversity of immunoglobulins and T cell receptors is largely due to the assembly of functional genes from separate segments. The mechanism by which these gene fragments are joined is starting to be deciphered, with broken DNA molecules that may be intermediates in the reaction providing a new clue.

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