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Review
. 1992:324:107-14.
doi: 10.1007/978-1-4615-3398-6_11.

Potential role of HBGF (FGF) and TGF-beta on prostate growth

Y Matuo  1 , W L McKeehan, G C Yan, S Nikolaropoulos, P S Adams, Y Fukabori, H Yamanaka, J Gaudreau
Affiliations
Review

Potential role of HBGF (FGF) and TGF-beta on prostate growth

Y Matuo et al. Adv Exp Med Biol. 1992.

Abstract

We review in this paper the role of heparin-binding growth factor (HBGF*) or fibroblast growth factor (FGF*), rat prostate cancer cells produce TGF-beta, IGF-II* and OGF*. Of these growth factors, TGF-beta and unknown labile factor with 19 kDa are the most probable candidates responsible for osteoblastic bony metastasis of prostate cancer. In vitro experiments suggest that TGF-beta modulates cell detachment of prostate cancer cells together with nutritional factors. HBGF-dependent growth of the prostate tumor epithelial cells is free from inhibition by TGF-beta, whereas normal prostate epithelial cells are sensitive to TGF-beta inhibition. Transfection experiments suggest that HBGF-2 (basic FGF) might be closely related to the malignant growth of prostate cancer, in addition to tumor angiogenesis.

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