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. 1975 Nov;27(11):849-54.
doi: 10.1111/j.2042-7158.1975.tb10228.x.

Determination of low cencentrations of the quaternary ammonium compound thiazinamium methylsulphate in plasma and urine

J G Jonkman, J Wijsbeek, S Hollenbeek, S H de Boer, R A de Zeeuw, L E Van Bork, N G Orie

Determination of low cencentrations of the quaternary ammonium compound thiazinamium methylsulphate in plasma and urine

J G Jonkman et al. J Pharm Pharmacol. 1975 Nov.

Abstract

A sensitive and selective method for the quantitative determination of the quaternary ammonium antiacetylcholine-compound thiazinamium methylsulphate (Multergan) in plasma and urine is described. The procedure is based on ion pair extraction of the compound with iodide as the counter ion. This is followed by gas chromatography using an alkali flame ionization detector. The detection limit is 2 ng ml-1 with a recovery of 88-0 +/- 6-2% from plasma, 91-4 +/- 4-6% from urine. The described method can also be applied to other quaternary ammonium compounds.

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