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. 1992 Aug 1;89(15):6968-72.
doi: 10.1073/pnas.89.15.6968.

Genetic and molecular analysis of recessive alleles at the pink-eyed dilution (p) locus of the mouse

M F Lyon  1 , T R King, Y Gondo, J M Gardner, Y Nakatsu, E M Eicher, M H Brilliant
Affiliations

Genetic and molecular analysis of recessive alleles at the pink-eyed dilution (p) locus of the mouse

M F Lyon et al. Proc Natl Acad Sci U S A. .

Abstract

Recessive mutant alleles at the pink-eyed dilution (p) locus on mouse chromosome 7 reduce pigmentation of both the coat and eyes. Here we describe the properties and complementation interactions of 10 p alleles, including 6 not previously reported. Several alleles that cause additional phenotypes affecting development, reproduction, and behavior were shown to be deletions by using DNA probes derived from the p region. An alignment of functional and marker-defined units is proposed, giving a linear complementation map that orders at least four functional loci. The characterization of a nested set of deletions around p will facilitate detailed molecular analyses of the genes and developmental functions associated with this part of the mouse genome.

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References

    1. Cell. 1979 Feb;16(2):225-37 - PubMed
    1. Genetics. 1982 Mar;100(3):427-53 - PubMed
    1. Science. 1991 Apr 26;252(5005):566-9 - PubMed
    1. Trends Genet. 1991 Jan;7(1):15-21 - PubMed
    1. Am J Med Genet. 1990 Mar;35(3):333-49 - PubMed

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