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. 1992 Aug 1;89(15):7252-6.
doi: 10.1073/pnas.89.15.7252.

Delineation of putative mechanisms involved in antibody-mediated clearance of rabies virus from the central nervous system

B Dietzschold  1 , M Kao, Y M Zheng, Z Y Chen, G Maul, Z F Fu, C E Rupprecht, H Koprowski
Affiliations

Delineation of putative mechanisms involved in antibody-mediated clearance of rabies virus from the central nervous system

B Dietzschold et al. Proc Natl Acad Sci U S A. .

Erratum in

  • Proc Natl Acad Sci U S A 1992 Oct 1;89(19):9365

Abstract

The in vitro biological activities of several rabies virus-neutralizing monoclonal antibodies (mAbs) were compared with their ability to prevent a lethal rabies virus encephalomyelitis. The protective activity of a particular mAb in vivo did not correlate with its virus-neutralizing activity in vitro; rather it was related to the mAb's ability to inhibit virus spread from cell to cell and to restrict rabies virus RNA transcription. Since treatment of rabies virus-infected cells with virus-neutralizing mAbs results in an endocytosis of the antibody, we hypothesize that an antibody may exert its inhibitory activity even after uptake by the cell. Post-exposure treatment of rats with a mAb that inhibited both virus spread and virus RNA transcription in vitro resulted in viral clearance from the central nervous system and protected the animals against a lethal rabies virus infection.

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