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Review
. 2004 Feb 15;9(4):173-81.
doi: 10.1016/S1359-6446(03)02978-7.

Analysis, statistical validation and dissemination of large-scale proteomics datasets generated by tandem MS

Alexey I Nesvizhskii  1 , Ruedi Aebersold
Affiliations
Review

Analysis, statistical validation and dissemination of large-scale proteomics datasets generated by tandem MS

Alexey I Nesvizhskii et al. Drug Discov Today. .

Abstract

Tandem mass spectrometry has been used increasingly for high-throughput analysis of complex protein samples. A major challenge lies in the consistent, objective and transparent analysis of the large amounts of data generated by such experiments and in their dissemination and publication. Here, we review currently available computational tools and discuss the need for statistical criteria in the analysis of large proteomics datasets.

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