Clinical Trial
doi: 10.1016/0278-5846(92)90025-a.
Valproate treatment of mania
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- PMID: 1496125
- DOI: 10.1016/0278-5846(92)90025-a
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Clinical Trial
Valproate treatment of mania
Prog Neuropsychopharmacol Biol Psychiatry.
1992 Sep.
Abstract
1. Acute as well as prophylactic effects of the anticonvulsant valproate are described in patients with mania and bipolar affective psychoses. 2. In a long-term evaluation of valproate prophylaxis ranging up to 14 years, an average improvement of the phase chart of 12 patients was observed by a factor of 12. 3. The mode of action of this effect appears to be related to the GABAergic properties of the compound.
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