[Nested case-control study on riboflavin levels in blood and urine and the risk of lung cancer]

Abstract

The present study is designed to explore the relationship between the riboflavin levels in blood and urine and the risk of lung cancer among miners in Yunnan Tin Corporation(YTC) by means of nested case-control design. Cases were patients with lung cancer newly diagnosed from 1992 to 1995. For each case, 2 controls were randomly matched with occupational exposure history, age, the time of collecting blood or urine samples. The indexes for evaluating the riboflavin nutritional status were erythrocyte glutathione reductase activation coefficient (EGR-AC) and the ratio of riboflavin and creatinine in urine. When analyzed as either the continuous or the rank variables, the odds ratios(ORs) used to estimate the relative risk of lung cancer have no statistical significance(P > 0.05) after adjusting the confusing factors. No association of riboflavin indexes in blood and urine with the lung cancer risk among YTC miners were observed in the present study.