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Review
. 2004 Mar;75(3):353-61.
doi: 10.1136/jnnp.2003.025825.

Cerebral perfusion and stroke

H S Markus  1
Affiliations
Review

Cerebral perfusion and stroke

H S Markus. J Neurol Neurosurg Psychiatry. 2004 Mar.

Abstract

Stroke is a heterogeneous syndrome caused by multiple disease mechanisms, but all result in a disruption of cerebral blood flow with subsequent tissue damage. This review covers the mechanisms responsible for regulation of the normal cerebral circulation, and how they are disrupted in disease states. A central concept in treating patients with acute ischaemic stroke is the existence of an ischaemic penumbra of potentially salvageable tissue, and the evidence for its existence in humans is reviewed.

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