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. 2004 Feb;2(2):E53.
doi: 10.1371/journal.pbio.0020053. Epub 2004 Feb 17.

New antibiotics--resistance is futile

Tabitha M Powledge  1
Affiliations

New antibiotics--resistance is futile

Tabitha M Powledge. PLoS Biol. 2004 Feb.

Abstract

It is the certain fate of all antibacterials to be fought off eventually by the pathogens they target. We need new ways to defeat disease, and we will need them forever

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Figures

Figure 1
Figure 1. TB Drug Resistance
This 40-year-old Estonian truck driver's TB is resistant to drugs and his right lung was removed three days before this picture was taken. (Photograph by WHO/STB/Colors Magazine/J. Langvad.)
Figure 2
Figure 2. Phage
Negative stain electron micrograph of the gamma phage from which the PlyG lytic enzyme was cloned for use to control B. anthracis. (Photograph courtesy of Vincent Fischetti and Raymond Schuch, The Rockefeller University.)
See this image and copyright information in PMC

References

    1. Artsimovitch I, Chu C, Lynch AS, Landick R. A new class of bacterial RNA polymerase inhibitor affects nucleotide addition. Science. 2003;302:650–654. - PubMed
    1. Berdis AJ, Lee I, Coward JK, Stephens C, Wright R, et al. A cell cycle-regulated adenine DNA methyltransferase from Caulobacter crescentus processively methylates GANTC sites on hemimethylated DNA. Proc Natl Acad Sci U S A. 1998;95:2874–2879. - PMC - PubMed
    1. Grundling A, Manson MD, Young R. Holins kill without warning. Proc Natl Acad Sci U S A. 2001;98:9348–9352. - PMC - PubMed
    1. Hopwood DA. Cracking the polyketide code. PLoS Biol. 2004;2:e35. doi: 10.1371/journal.pbio.0020035. - DOI - PMC - PubMed
    1. Kohli RM, Walsh CT, Burkart MD. Biomimetic synthesis and optimization of cyclic peptide antibiotics. Nature. 2002;418:658–661. - PubMed

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