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Review
. 2004 Feb 13;13(3):302-4.
doi: 10.1016/s1097-2765(04)00055-3.

A protein interaction domain contacts RNA in the prespliceosome

Brenton R Graveley  1
Affiliations
Free article
Review

A protein interaction domain contacts RNA in the prespliceosome

Brenton R Graveley. Mol Cell. .
Free article

Abstract

SR proteins bind to exons and recruit the spliceosome via protein interactions mediated by an arginine-serine-rich (RS) domain. In this issue of Molecular Cell, demonstrate that the RS domain of SR proteins contacts the pre-mRNA branchpoint, indicating that these domains participate in both protein and RNA interactions.

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