Cumulative first live birth after elective cryopreservation of all embryos due to ovarian hyperresponsiveness

Abstract

Objective: To estimate cumulative chance for first live birth after elective pronuclear stage cryopreservation of all embryos due to ovarian hyperresponsiveness.

Design: Retrospective analysis with longitudinal follow-up.

Setting: Academic hospital.

Patient(s): Thirty subjects with elective cryopreservation of all embryos due to ovarian hyperresponsiveness.

Intervention(s): Elective cryopreservation of all embryos at the pronuclear stage (n = 30) and subsequent cryopreserved-thawed ET (n = 51).

Main outcome measure(s): Cumulative chance for first live birth.

Result(s): Cumulative chance for first live birth was 77% when analyzed by intention to treat and 82% by treatment with ET. Nearly 40% of live births were multiple.

Conclusion(s): Cumulative first live birth increased with repetitive ET after elective pronuclear stage cryopreservation of all embryos due to ovarian hyperresponsiveness. Multiple births, however, were frequent. In the context of initial ET attempts in young women, transfer of no more than two cryopreserved-thawed embryos is advised.