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Review
. 2004 Mar 1;58(3):927-31.
doi: 10.1016/j.ijrobp.2003.09.092.

The contribution of epidermal growth factor receptor (EGFR) signaling pathway to radioresistance in human gliomas: a review of preclinical and correlative clinical data

Arnab Chakravarti  1 , Adam Dicker, Minesh Mehta
Affiliations
Review

The contribution of epidermal growth factor receptor (EGFR) signaling pathway to radioresistance in human gliomas: a review of preclinical and correlative clinical data

Arnab Chakravarti et al. Int J Radiat Oncol Biol Phys. .

Abstract

Purpose: The epidermal growth factor receptor (EGFR) pathway is frequently upregulated in high-grade gliomas via gene amplification and by specific mutations that render EGFR constitutively active (EGFRvIII).

Methods and materials: This review highlights EGFR's role in mediating radiation resistance in gliomas: underlying molecular mechanisms, with discussion of relevant preclinical and clinical correlative data.

Results: Preclinical and emerging clinical data suggest that EGFR signaling plays a potentially important role in mediating radiation resistance in human gliomas.

Conclusions: Targeting EGFR alone, or in combination with its downstream mediators, represents a promising new approach for the management of glioma patients.

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