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Comparative Study
. 2004 Feb 5;121(1-2):146-50.
doi: 10.1016/j.molbrainres.2003.11.008.

Transforming growth factor beta receptor family ligands inhibit hepatocyte growth factor synthesis and secretion from astrocytoma cells

Naibedya Chattopadhyay  1 , Jacob T-Felt Hansen, Madan M Godbole, Edward M Brown
Affiliations
Comparative Study

Transforming growth factor beta receptor family ligands inhibit hepatocyte growth factor synthesis and secretion from astrocytoma cells

Naibedya Chattopadhyay et al. Brain Res Mol Brain Res. .

Abstract

Transforming growth factor beta (TGFbeta) and hepatocyte growth factor (HGF) promote glioma progression. Using U87human astrocytoma cells, which express TGFbeta receptors (TbetaRs), we show (1) mRNA expression of Smads (2, 3, 4), bone morphogenetic protein (BMP)- and activin-A receptors; (2) TGFbeta1 inhibits and HGF induces proliferation; (3) TGFbeta1 and activin-A equipotently inhibit HGF secretion more than BMP-2, but none alters c-Met expression. Because interfering with TbetaR signaling might nullify the beneficial inhibition of HGF secretion, activin-A should instead be considered for combination glioma therapy.

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