doi: 10.1002/gepi.1370010211.
Genetic Analysis Workshop II: results of incorporating a linkage disequilibrium parameter
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- PMID: 14971367
- DOI: 10.1002/gepi.1370010211
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Genetic Analysis Workshop II: results of incorporating a linkage disequilibrium parameter
Genet Epidemiol.
1984.
Abstract
The corporation of a linkage disequilibrium parameter, delta, into linkage analysis is illustrated for data from Genetic Analysis Workshop II. Points from a joint likelihood surface are calculated and displayed on a recombination fraction-linkage disequilibrium grid using a simple modification of LIPED. The approach is shown to increase the power of linkage analysis and the power of tests for heterogeneity of linkage for the simulated examples.
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