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Comparative Study
. 2004 Jan;255(1-2):87-92.
doi: 10.1023/b:mcbi.0000007264.37170.39.

The gender differences in health effects of environmental cadmium exposure and potential mechanisms

Muneko Nishijo  1 , Soisungwan Satarug, Ryumon Honda, Ikiko Tsuritani, Keiko Aoshima
Affiliations
Comparative Study

The gender differences in health effects of environmental cadmium exposure and potential mechanisms

Muneko Nishijo et al. Mol Cell Biochem. 2004 Jan.

Abstract

On a viewpoint of gender differences in Cd body burden and its health effects, we reviewed the population-based research including our own which conducted in Japan, Thailand, Australia, Poland, Belgium and Sweden to assess health effects of human exposure to environmental cadmium and their potential mechanisms. As a result, six risk factors in Cd health effects in women have been identified; (1) more serious type of renal tubular dysfunction, (2) difference in calcium metabolism and its regulatory hormones, (3) kidney sensitivity; difference in P450 phenotype, (4) pregnancy, (5) body iron store status, and (6) genetic factors. Further studies of Cd toxicity targeted to women would now appear necessary.

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