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Review
. 2004;20(1):49-58.
doi: 10.1023/B:GLYC.0000016742.88750.1a.

Ganglioside/protein kinase signals triggering cytoskeletal actin reorganization

Hideyoshi Higashi  1 , Nai Hong Chen
Affiliations
Review

Ganglioside/protein kinase signals triggering cytoskeletal actin reorganization

Hideyoshi Higashi et al. Glycoconj J. 2004.

Abstract

Exposure of neuronal cells to nanomolar concentrations of oligosaccharide portions of ganglioside GM2 and GT1b stimulates cAMP-dependent protein kinase (PKA) Ca2+/calmodulin-dependent protein kinase II (CaMKII), respectively, in a few seconds suggesting the presence of glyco-receptor-like molecules on the surface of the cells. Both GM2/PKA (GalNAc/PKA) and GT1b/CaMKII signaling cascades induced cytoskeletal actin reorganization through Cdc42 activation leading to filopodia formation within 2 min. Long-term effects of these glyco-signals were facilitation of dendritic differentiation of primary cultured hippocampal neurons and cerebellar Purkinje neurons indicating physiological roles of the signals in neuronal differentiation and maturation.

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