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. 2003 Nov-Dec;45(6):431-8.

[DDT/DDE concentrations and risk of hypospadias. Pilot case-control study]

[Article in Spanish]
Silvia Flores-Luévano  1 , Paulina Farías, Mauricio Hernández, Patricia Romano-Riquer, Jean Philippe Weber, Eric Dewailly, Juan Cuevas-Alpuche, Isabelle Romieu
Affiliations
  • PMID: 14974286

[DDT/DDE concentrations and risk of hypospadias. Pilot case-control study]

[Article in Spanish]
Silvia Flores-Luévano et al. Salud Publica Mex. 2003 Nov-Dec.

Abstract

Objective: To evaluate the association between maternal serum DDT/DDE levels and risk of hypospadias.

Material and methods: A case-control study in Mexico City was conducted during 1997-1999 among 41 subjects with hypospadias and 28 controls. Blood samples were obtained from study subjects. Information was obtained using a standardized questionnaire. Data were analyzed using multivariate logistic regression models.

Results: Maternal DDT and DDE levels showed no association with hypospadias (OR 1.13; 95% CI 0.24-5.29 and OR = 0.48; 95% CI 0.15-1.60, respectively). Associated factors were older age of mothers (OR 8.69; 95% CI 1.69-44.9), and working during pregnancy (OR 4.68; 95% CI 1.15-18.9).

Conclusions: Information about the endocrine effects of different levels of DDT/DDE in human subjects is scarce; dosage may be a determinant factor of the type of effect. The English version of this paper is available at:http://www.insp.mx/salud/index.html.

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