Comparative Study
doi: 10.1016/0006-291x(92)90833-7.
A homology domain shared between Drosophila optomotor-blind and mouse Brachyury is involved in DNA binding
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- PMID: 1497674
- DOI: 10.1016/0006-291x(92)90833-7
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Comparative Study
A homology domain shared between Drosophila optomotor-blind and mouse Brachyury is involved in DNA binding
Biochem Biophys Res Commun.
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Abstract
The distribution of sequence elements divides the optomotor-blind protein into three regions and is suggestive of a transcriptional regulatory role of this protein. The central region of Omb is homologous to the N-terminal half of the Brachyury protein. The conserved domain of Omb is here shown to possess general DNA binding affinity but has no significant similarity to recognized DNA binding motifs.
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