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Comparative Study
. 1992 Jul 31;186(2):918-25.
doi: 10.1016/0006-291x(92)90833-7.

A homology domain shared between Drosophila optomotor-blind and mouse Brachyury is involved in DNA binding

G O Pflugfelder  1 , H Roth, B Poeck
Affiliations
Comparative Study

A homology domain shared between Drosophila optomotor-blind and mouse Brachyury is involved in DNA binding

G O Pflugfelder et al. Biochem Biophys Res Commun. .

Abstract

The distribution of sequence elements divides the optomotor-blind protein into three regions and is suggestive of a transcriptional regulatory role of this protein. The central region of Omb is homologous to the N-terminal half of the Brachyury protein. The conserved domain of Omb is here shown to possess general DNA binding affinity but has no significant similarity to recognized DNA binding motifs.

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