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Multicenter Study
. 2004 Mar;89(3):230-1.
doi: 10.1136/adc.2002.023614.

Alpha1 antitrypsin and the prevalence and severity of asthma

O S von Ehrenstein  1 , E M Maier, S K Weiland, D Carr, T Hirsch, T Nicolai, A A Roscher, E von Mutius
Affiliations
Multicenter Study

Alpha1 antitrypsin and the prevalence and severity of asthma

O S von Ehrenstein et al. Arch Dis Child. 2004 Mar.

Abstract

In a random sample of children (aged 9-11 years; n = 5629), who were studied according to the ISAAC phase II protocol, heterozygosity of the alpha1 antitrypsin (alpha1-AT) Pi genotypes MS or MZ, or low alpha1-AT plasma levels, were not associated with an increased risk of developing asthma. Asthmatics with low levels of alpha1-AT were particularly prone to develop airway hyperresponsiveness and reduced lung function.

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