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Review
. 2004 Mar;32(3):281-90.
doi: 10.1124/dmd.32.3.281.

Glucuronidation and the UDP-glucuronosyltransferases in health and disease

Peter G Wells  1 , Peter I Mackenzie, Jayanta Roy Chowdhury, Chantal Guillemette, Philip A Gregory, Yuji Ishii, Antony J Hansen, Fay K Kessler, Perry M Kim, Namita Roy Chowdhury, Joseph K Ritter
Affiliations
Review

Glucuronidation and the UDP-glucuronosyltransferases in health and disease

Peter G Wells et al. Drug Metab Dispos. 2004 Mar.

Abstract

This article is an updated report of a symposium held at the June 2000 annual meeting of the American Society for Pharmacology and Experimental Therapeutics in Boston. The symposium was sponsored by the ASPET Divisions for Drug Metabolism and Molecular Pharmacology. The report covers research from the authors' laboratories on the structure and regulation of UDP-glucuronosyltransferase (UGT) genes, glucuronidation of xenobiotics and endobiotics, the toxicological relevance of UGTs, the role of UGT polymorphisms in cancer susceptibility, and gene therapy for UGT deficiencies.

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