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Comparative Study
. 2004 Feb;94(2):211-3.
doi: 10.1254/jphs.94.211.

Characterization of GABAB receptor in the human colon

Yasuhito Uezono  1 , Muneshige Kaibara, Hideki Hayashi, Shunsuke Kawakami, Akihito Enjoji, Takashi Kanematsu, Kohtaro Taniyama
Affiliations
Free article
Comparative Study

Characterization of GABAB receptor in the human colon

Yasuhito Uezono et al. J Pharmacol Sci. 2004 Feb.
Free article

Abstract

Characterization of the GABA(B) receptor in the human colon was performed by the reverse transcription-polymerase chain reaction (RT-PCR). mRNAs for both subunits of the GABA(B) receptor, GABA(B1) and GABA(B2), were detected in the human colon. The GABA(B1(e)) isoform was detected in the human colon, but not in the brain, and the other isoforms, except GABA(B1(d)), were detected in both tissues. Thus, the GABA(B) receptor may be present as a heterodimer with subunits of GABA(B1) and GABA(B2) in the human colon.

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