Review
doi: 10.1002/jgm.533.
Protection and selection for gene therapy in the hematopoietic system
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- PMID: 14978767
- DOI: 10.1002/jgm.533
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Review
Protection and selection for gene therapy in the hematopoietic system
J Gene Med.
2004 Feb.
Abstract
Hematopoietic stem cell gene therapy is potentially curative for a number of inherited and acquired disorders. However, poor gene transfer and expression in repopulating hematopoietic stem cells attenuate this potential. Here we review potential means of conferring a selective advantage to hematopoietic stem cells and their progeny, and discuss the issues that surround the use of selective advantages in vivo.
Copyright 2004 John Wiley & Sons, Ltd.
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