Evolving views of involution
- PMID: 14979913
- PMCID: PMC400663
- DOI: 10.1186/bcr765
Evolving views of involution
Abstract
The developmental preparation of the mammary gland for milk production that occurs during pregnancy is followed by an equally dramatic process of involution as the gland returns to its prepregnancy state. Two detailed, microarray-based surveys reported in this issue extend our understanding of the nature and timing of molecular and cellular events in involution that underlie these developmental changes.
Comment on
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Involution of the mouse mammary gland is associated with an immune cascade and an acute-phase response, involving LBP, CD14 and STAT3.Breast Cancer Res. 2004;6(2):R75-91. doi: 10.1186/bcr753. Epub 2003 Dec 18. Breast Cancer Res. 2004. PMID: 14979920 Free PMC article.
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Gene expression profiling of mammary gland development reveals putative roles for death receptors and immune mediators in post-lactational regression.Breast Cancer Res. 2004;6(2):R92-109. doi: 10.1186/bcr754. Epub 2003 Dec 18. Breast Cancer Res. 2004. PMID: 14979921 Free PMC article.
References
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