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Review
. 2004;6(2):89-92.
doi: 10.1186/bcr765. Epub 2004 Feb 10.

Evolving views of involution

Affiliations
Review

Evolving views of involution

Stephen R Master et al. Breast Cancer Res. 2004.

Abstract

The developmental preparation of the mammary gland for milk production that occurs during pregnancy is followed by an equally dramatic process of involution as the gland returns to its prepregnancy state. Two detailed, microarray-based surveys reported in this issue extend our understanding of the nature and timing of molecular and cellular events in involution that underlie these developmental changes.

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References

    1. Stein T, Morris JS, Davies CR, Weber-Hall SJ, Duffy M-A, Heath VJ, Bell AK, Ferrier RK, Sandilands GP, Gusterson BA. Involution of the mouse mammary gland is associated with an immune cascade and an acute-phase response, involving LBP, CD14, and STAT3. Breast Cancer Res. 2004;6:R75–R91. doi: 10.1186/bcr753. - DOI - PMC - PubMed
    1. Clarkson RWE, Wayland MT, Lee J, Freeman T, Watson CJ. Gene expression profiling of mammary gland development reveals putative roles for death receptors and immune mediators in post-lactational regression. Breast Cancer Res. 2004;6:R92–R109. doi: 10.1186/bcr754. - DOI - PMC - PubMed
    1. Lemkin PF, Thornwall GC, Walton KD, Hennighausen L. The microarray explorer tool for data mining of cDNA microarrays: application for the mammary gland. Nucleic Acids Res. 2000;28:4452–4459. doi: 10.1093/nar/28.22.4452. - DOI - PMC - PubMed
    1. Master SR, Hartman JL, d'Cruz CM, Moody SE, Keiper EA, Ha SI, Cox JD, Belka GK, Chodosh LA. Functional microarray analysis of mammary organogenesis reveals a developmental role in adaptive thermogenesis. Mol Endocrinol. 2002;16:1185–1203. - PubMed
    1. D'Cruz CM, Moody SE, Master SR, Hartman JL, Keiper EA, Imielinski MB, Cox JD, Wang JY, Ha SI, Keister BA, Chodosh LA. Persistent parity-induced changes in growth factors, TGF-β3, and differentiation in the rodent mammary gland. Mol Endocrinol. 2002;16:2034–2051. doi: 10.1210/me.2002-0073. - DOI - PubMed

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