Coordinating synaptic growth without being a nervous wreck
- PMID: 14980197
- DOI: 10.1016/s0896-6273(04)00078-9
Coordinating synaptic growth without being a nervous wreck
Abstract
The function and regulation of actin-cytoskeletal dynamics during synaptic growth is poorly understood. In this issue of Neuron, Coyle et al. report the identification of nervous wreck (nwk), a synapse-specific adaptor molecule in Drosophila that regulates synaptic growth and morphology via Wasp, a well-characterized mediator of actin dynamics.
Comment on
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Cytoskeletal dynamics and transport in growth cone motility and axon guidance.Neuron. 2003 Oct 9;40(2):209-27. doi: 10.1016/s0896-6273(03)00633-0. Neuron. 2003. PMID: 14556705 Review.
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Nervous wreck, an SH3 adaptor protein that interacts with Wsp, regulates synaptic growth in Drosophila.Neuron. 2004 Feb 19;41(4):521-34. doi: 10.1016/s0896-6273(04)00016-9. Neuron. 2004. PMID: 14980202
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