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Comment
. 2004 Feb 20;116(4):483-5.
doi: 10.1016/s0092-8674(04)00165-5.

Mysteries of the transferrin-transferrin receptor 1 interaction uncovered

D R Richardson  1
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Mysteries of the transferrin-transferrin receptor 1 interaction uncovered

D R Richardson. Cell. .
Free article

Abstract

How does the iron (Fe) binding protein, transferrin (Tf), bind to the transferrin receptor 1 (TfR1) to donate Fe to cells? In this issue of Cell, Cheng et al., describe the molecular structure of the human TfR1-Tf complex, This atomic model shows that Tf binds laterally to the TfR1 dimer and extends into the gap between the bottom of the receptor ectodomain and the membrane.

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